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About

Launched in 2016, Israel Haifa based Paragate Medical is an innovative device company, aiming to revolutionize the heart failure epidemic management by shifting the weight of chronic disease treatment out of the hospital towards home-based care.

Our Mission is to reduce fluid overload in Chronic Heart and Kidney Failure patients, the greatest burden on the healthcare system.

Prevention Requires Action. Paragate is set to break the vicious cycle for fluid overload and provide a chronic, active solution for this chronic condition.

Our Team

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Zohar Gendler

Chairman

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Nizar Mishael

CFO

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Nitai Hanani

CEO & Co-founder

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Dr. Yair Feld

Medical Director & Founder

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Jose (“Pepe”) Calle Gordo

Board Member

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Rann Marom

VP Business Development

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Inbal Eyal

VP Clinical Affairs

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Zohar Gendler

Chairman

CEO and managing partner of NGT VC. Former CEO and director of Beta-O2 Technologies (a biomedical company which developed proprietary.

Implantable bio-artificial pancreas) for a period of 8 years, brought the company to one of the world leaders positioning in the area.

Served as CEO of the Technion Entrepreneurial Incubator (TEIC) for a period of 11 years.

Led the establishment and investment in more than 40 companies, such as Prolor Biotech (Opko), Mazor Robotics (Medtronic), Corindus (Siemens), ReWalk (NASDAQ: RWLK) and many others. Gained a wide range of experience in identifying new technologies and in establishing, directing, and creating value for technology-based start-up companies.

M.Sc. in material engineering, B.Sc. in physics, and MBA, all from the Technion, Israel Institute of Technology

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Nizar Mishael

CFO

Nizar serves as the Managing Partner and Chief Financial Officer for New Generation Technology (NGT) VC, where he supported over thirty portfolio companies.

He managed the finances of these companies with strong leadership, closely following the budget, making sure the companies receive their full government money, and ensuring they set goals and achieve what they should (and when) with their funds. He has also taken an active role with follow-on funding and handling complex investment transactions.

Previously, Nizar was the Chairman and Director of Positive Care. He holds Certified Public Accountant license with Greenberg & Shneor and holds a M.B.A. from Tel Aviv University.

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Nitai Hanani

CEO & Co-founder

Over seventeen years of experience in cardiovascular and neuromodulation medical devices field in various R&D, engineering and management positions, from which seven with Enopace Biomedical – pioneering the conceptualization and development of intravascular neurostimulation device for treatment of heart failure.

Involved with companies in the fields of stroke treatment, renal denervation, peripheral interventional, acute kidney injury and ventilation monitoring. B.Sc., M.Sc. in Biomedical Engineering, Technion-IIT, Haifa, Israel Graduate project spun-off as startup (Pneumedicare) for ventilation monitoring.

Conducted research in Cardiac Resynchronization Therapy, awarding him as young investigator award of the Israeli Society for Heart Research (ISHR).

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Dr. Yair Feld

Medical Director & Founder

Dr. Yair Feld is the director of structural and interventional cardiology unit at Tzafon Medical Center (Poria) Affiliated with Azrieli Faculty of Medicine, Bar Ilan University.

Prior to that, Yair practiced as interventional cardiologist and head of innovation lab at Rambam Healthcare Campus and performed his fellowship in Sunnybrook Toronto. Yair has over 25 years of experience in managing life science companies and leading innovative research and development projects.

He founded several medical technology companies among which Proarc, HVT, Cathalert Corassist Cardiovascular and Cuspa. Yair received his MD and PhD (physiology and biophysics) from the Technion-Israel Institute of Technology, as well as a BA is Physics from the University of Tel-Aviv.

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Jose (“Pepe”) Calle Gordo

Board Member

A global medical device executive with over 30 years of business experience.

Jose has had general management and functional responsibility in a broad spectrum of roles, including General/Executive Management, CEO and Board responsibilities as well as leadership roles in Research & Development, Clinical Research, Market Development and Sales & Marketing. As a pillar of cardiovascular MedTech industry, Jose serves as the director of the PCR innovators day course. Most recently, he served as CEO and director of BIOSENSORS International, where he build a multinational management team an

d lead the transformation and expansion of Biosensors from a start up to a recognized multi-national in Vascular Intervention.

Prior to joining BIOSENSORS, he held several leadership roles at ABBOTT (Structural Heart & Vascular) and GUIDANT.

Jose started his career at Eli Lilly where he had a number of commercial roles with growing responsibility in the field of cardiac devices. Jose Calle Gordo holds an electrical engineering degree (BSc) from the Universidad Politecnica de Madrid, Spain.

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Rann Marom

VP Business Development

Rann is a seasoned executive with an extensive record planning and executing go-to-market strategies, developing business and scaling innovative Israel-based technology companies globally.

His recent senior management roles include opening the Indian market at RADA, a market-leading software-defined radar company acquired by a global top-10 defense conglomerate, and growing US revenues 5x at an education SAAS company through a strategic partnership. Previously, he was a partner at Veritas, Israel’s first venture capital firm, where he led global fundraising as well as seed and early-stage investments in medical device and communications companies.

Rann as an MBA from INSEAD and a BSc in Aerospace Engineering from the Technion.

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Inbal Eyal

VP Clinical Affairs

Inbal brings over 16 years of experience in global clinical research, with a demonstrated record of successfully leading clinical trials, strategy, and operations.

For the past years, Inbal has led the Clinical Affairs department at Medtronic Yokneam, a global company developing medical technology in various fields. Previously, she held the position of Clinical Affairs Director at Enzymotec Ltd., which operated in both pharmaceutical and nutrition markets.

Inbal possesses a comprehensive knowledge of ICH-GCP, ISO 14155, and FDA regulations. Inbal holds both an M.Sc. in Medical Science and an MBA in Business Administration from the Technion Institute of Technology.

Scientific Advisory Board

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Prof. Piotr Ponikowski

SAB Member

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Dr. Maria Rosa Costanzo

SAB Member

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Prof. Uri Elkayam

SAB Member

Piotr_Ponikowski

Prof. Piotr Ponikowski

SAB Member

Piotr Ponikowski MD, PhD, FESC, is Head of the Department of Heart Diseases, Wroclaw Medical University and Head of the Cardiology Department at the Center for Heart Diseases at 4th Military Hospital, Wroclaw, Poland.

Former president of the European Heart Failure Association and Chair of the European Guidelines for HF management. His research interests mainly include heart failure (HF), coronary artery disease and cardiac arrhythmias. He has been involved in numerous research projects, such as the benefits of physical rehabilitation in patients with chronic HF, assessment of metabolic derangements in HF (with special interest in iron deficiency), evaluation of reflex control in the cardiorespiratory system in order to optimize assessment and management of patients with HF. He has been involved in numerous clinical trials as main investigator, member of international steering committees, endpoint committees and advisory boards.

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Dr. Maria Rosa Costanzo

SAB Member

Dr Costanzo Maria Rosa Costanzo, MD, FESC, FACC, FHSA, is a Worldwide Leading Researcher in Ultrafiltration Therapy. She is Medical Director of the Heart Failure Program with Midwest Heart Specialists, and Medical Director of the Edward Center for Advanced Heart Failure in Naperville, Illinois.

Dr Costanzo was Director of the Loyola University Chicago Heart Failure and Cardiac Transplant Program between 1988 and 1994, and of the Rush Heart Failure and Cardiac Transplant Program between 1994 and 2001. She is a Member of the Research Committee of the Heart Failure Society of America (HFSA). Between 1995 and 2000, Dr Costanzo was Editor in Chief of the Journal of Heart and Lung Transplantation. She has published more than 150 peer-reviewed manuscripts and is the author of numerous review papers, monographs, and book chapters.

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Prof. Uri Elkayam

SAB Member

Uri Elkayam, MD FHSA, is a Professor of Medicine and a Professor of Obstetrics and Gynecology at the University of Southern California. He is a nationally and internationally known expert in heart failure and heart disease in pregnancy.

Dr Elkayam is a past member of the executive council of the Heart Failure Society of America and the chairman of its corporate affairs committee. He is a present or past editorial board member of the Journal of the American College of Cardiology, American Journal of Cardiology, Journal of Cardiac Failure, Heart Failure, Heart Failure Reviews, Journal of Preventive Cardiology and Cardiology in Review.

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